منابع مشابه
Hilar mossy cells of the dentate gyrus: a historical perspective
THE CIRCUITRY OF THE DENTATE GYRUS (DG) OF THE HIPPOCAMPUS IS UNIQUE COMPARED TO OTHER HIPPOCAMPAL SUBFIELDS BECAUSE THERE ARE TWO GLUTAMATERGIC PRINCIPAL CELLS INSTEAD OF ONE: granule cells, which are the vast majority of the cells in the DG, and the so-called "mossy cells." The distinctive appearance of mossy cells, the extensive divergence of their axons, and their vulnerability to excitotox...
متن کاملLocal and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus
Hilar mossy cells are the prominent glutamatergic cell type in the dentate hilus of the dentate gyrus (DG); they have been proposed to have critical roles in the DG network. To better understand how mossy cells contribute to DG function, we have applied new viral genetic and functional circuit mapping approaches to quantitatively map and compare local and long-range circuit connections of mossy...
متن کاملThe dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies).
The dentate gyrus is a simple cortical region that is an integral portion of the larger functional brain system called the hippocampal formation. In this review, the fundamental neuroanatomical organization of the dentate gyrus is described, including principal cell types and their connectivity, and a summary of the major extrinsic inputs of the dentate gyrus is provided. Together, this informa...
متن کاملTranslamellar disinhibition in the rat hippocampal dentate gyrus after seizure-induced degeneration of vulnerable hilar neurons.
Longitudinally restricted axonal projections of hippocampal granule cells suggest that transverse segments of the granule cell layer may operate independently (the "lamellar" hypothesis). Longitudinal projections of excitatory hilar mossy cells could be viewed as antithetical to lamellar function, but only if longitudinal impulse flow effectively excites distant granule cells. We, therefore, de...
متن کاملRAPID COMMUNICATION Expression of C-fos in Hilar Mossy Cells of the Dentate Gyrus In Vivo
Granule cells (GCs) of the dentate gyrus (DG) are considered to be quiescent—they rarely fire action potentials. In contrast, the other glutamatergic cell type in the DG, hilar mossy cells (MCs) often have a high level of spontaneous activity based on recordings in hippocampal slices. MCs project to GCs, so activity in MCs could play an important role in activating GCs. Therefore, we investigat...
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ژورنال
عنوان ژورنال: Behavioral and Brain Sciences
سال: 2016
ISSN: 0140-525X,1469-1825
DOI: 10.1017/s0140525x15001818